Product Description for MGMT
MGMT.
Presentation: Purified
Presentation: Purified
Properties for MGMT
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | 6-O-methylguanine-DNA methyltransferase, Methylated-DNA-protein-cysteine methyltransferase, O-6-methylguanine-DNA-alkyltransferase |
| Presentation | Purified |
| Molecular weight | 23.8 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % by SDS - PAGE |
| Background | O-6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and is involved in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. There are few reports that abnormal MGMT expression correlates with the prognosis in human solid cancers. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Matsukura S., et al. (2001) Annals of Surgical Oncology, 8(10):807--816Esteller M.,et al. (2002) J Natl Cancer Inst. 2, 26-32. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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