Product Description for HFE / HLAH
HFE / HLAH.
Presentation: Purified
Presentation: Purified
Properties for HFE / HLAH
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | Hereditary hemochromatosis protein |
| Presentation | Purified |
| Molecular weight | 35.7 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 85 % by SDS - PAGE |
| Background | HFE, also known as HLA-H, belongs to the MHC class I family. This protein contains 1 Ig-like C1-type (immunoglobulin-like) domain. HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta-2 microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor (TFR) with transferrin. It binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| General Readings | Feder J.N., et al. (1998) Proc. Natl. Acad. Sci. U.S.A. 95:1472-1477West, A P, et al. (2000) J. Biol. Chem. (UNITED STATES) 275 (49): 38135–8. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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