IRGM (23-181, His-tag) - AR50657PU-N

Product Description for IRGM

IRGM.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.5 mg
Synonyms	IFI1, IRGM1, Immunity-related GTPase family M protein, LRG-47, LRG47, MGC149263, MGC149264
Presentation	Purified
Molecular weight	20.1 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: F8VPC9
Purity	> 90 % by SDS - PAGE
Background	Immunity-related GTPase family M protein, also known as IRGM, is required for clearance of acute protozoan and bacterial infections. This protein functions in innate immune response probably through regulation of autophagy. It may regulate proinflammatory cytokine production and prevent endotoxemia upon infection and may also play a role in macrophages adhesion and motility.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Singh S.B., et al. (2006) Science. 313:1438-1441Parkes M., et al. (2007) Nat. Genet. 39:830-832
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human IRGM protein, fused to His-tag at N-terminus, was expressed in E.coli. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MKETLKIVSR TPVNITMAGD SGNGMSTFIS ALRNTGHEGK ASPPTELVKA TQRCASYFSS HFSNVVLWDL PGTGSATTTL ENYLMEMQFN RYDFIMVASA QFSMNHVMLA KTAEDMGKKF YIVWTKLDMD LSTGALPEVQ LLQIRENVLE NLQKERVCEY` Molecular weight: (180aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 2M urea, 10% glycerol Purity: >90% by SDS - PAGE State: Liquid purified protein Purified