Product Description for TFB2M
TFB2M.
Presentation: Purified
Presentation: Purified
Properties for TFB2M
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | Dimethyladenosine transferase 2 mitochondrial, Hepatitis C virus NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, N'-adenosyl(rRNA) dimethyltransferase 2, NS5ATP5, S-adenosylmethionine-6-N', mtTFB2 |
| Presentation | Purified |
| Molecular weight | 45.8 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 90 % by SDS - PAGE |
| Background | TFB2M is S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. This protein is also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. TFB2M stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Litonin,D.,et al. (2010) J. Biol. Chem. 285 (24), 18129-18133Norrbom,J.,et al. (2010) Acta Physiol (Oxf) 198 (1), 71-79. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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