Product Description for Calcipressin-3
Calcipressin-3.
Presentation: Purified
Presentation: Purified
Properties for Calcipressin-3
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | DSCR1L2, Down syndrome candidate region 1-like protein 2, Myocyte-enriched calcineurin-interacting protein 3, RCAN3, Regulator of calcineurin 3 |
| Presentation | Purified |
| Molecular weight | 23.5 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | Calcipressin-3, also known as RCAN3, is a 241 amino acid protein that potentially is involved in central nervous system development. RCAN3 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Overexpression of calcipressin-3 results in inhibition of calcineurin activity towards the nuclear factor of activated T-cells (NFAT) transcription factors and also downregulates NFAT-dependent cytokine gene expression in activated Jurkat T-cells. Highest expression occurs in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Strippoli P., et al. (2000) Genomics. 64:252-263.Abbasi S., et al. (2006) J Biol Chem. 281:7717-7726. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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