TSC22D3 (1-134, His-tag) - AR50584PU-S

Product Description for TSC22D3

TSC22D3.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	50 µg
Synonyms	DSIP-immunoreactive peptide, DSIPI, Delta sleep-inducing peptide immunoreactor, GILZ, Glucocorticoid-induced leucine zipper protein, TSC-22-like protein, TSC-22R, TSC22 domain family protein 3
Presentation	Purified
Molecular weight	17.2 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q99576
Purity	> 85 % by SDS - PAGE
Background	TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Asselin-Labat M.-L., et al. (2004) Blood. 104:215-223Berrebi D., et al. (2003) Blood. 101:729-738
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV` Molecular weight: (157aa) confirmed by MALDI-TOF
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT Purity: >85% by SDS - PAGE State: Liquid purified protein Purified