Product Description for EIF4H / WBSCR1
EIF4H / WBSCR1.
Presentation: Purified
Presentation: Purified
Properties for EIF4H / WBSCR1
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | Eukaryotic translation initiation factor 4H, KIAA0038, WSCR1, Williams-Beuren syndrome chromosomal region 1 protein, eIF-4H |
| Presentation | Purified |
| Molecular weight | 29.9 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | Eukaryotic translation initiation factor 4H, also known as EIF4H, is a 248 amino acid protein that localizes to the perinuclear region of the cytoplasm and is expressed as two isoforms, designated short and long. EIF4H induces the RNA-dependent ATP hydrolysis catalyzed by the initiation factors EIF4A and EIF4B. EIF4H was further shown to stimulate the initial rate and extent of EIF4A-mediated mRNA secondary structure unwinding. Defects in the gene encoding EIF4H are associated with Williams- Beuren syndrome (WBS), a rare developmental disorder characterized by cardiovascular and musculo-skeletal abnormalities. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Richter Cook N J., et al. (1998) J Biol Chem. 273:7579-7587.Doepker R C., et al. (2004) J Virol. 78: 4684-4699. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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