Product Description for HAAO
HAAO.
Presentation: Purified
Presentation: Purified
Properties for HAAO
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | 3-HAO, 3-hydroxyanthranilate 3, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, 4-dioxygenase, HAD |
| Presentation | Purified |
| Molecular weight | 35 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | HAAO is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. This protein catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. |
| Concentration | 0.5mg/ml (determined by BCA assay) |
| General Readings | Malherbe P., et al. (1994) J Biol Chem. 13;269(19):13792-7. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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