CBX3 (1-183, His-tag) - AR50281PU-S

Product Description for CBX3

CBX3.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	Chromobox protein homolog 3, HECH, HP1 gamma, HP1-gamma, HP1Hs-gamma, Heterochromatin protein 1 homolog gamma, Modifier 2 protein
Presentation	Purified
Molecular weight	23.4 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q13185
Purity	> 90 % by SDS - PAGE
Background	CBX3, also known as chromobox protein homolog 3, seems to be involved in transcriptional silencing in heterochromatin-like complexes. This protein recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. It involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Koike N., et al. (2000) FEBS Lett. 467:17-21Lachner M., et al. (2001) Nature. 410:116-120
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human CBX3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MGSHMASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ` Molecular weight: (207aa), confirmed by MALDI-TOF
Format	Buffer System: 20 mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT Purity: >90% by SDS - PAGE State: Liquid purified protein Purified