Product Description for PSMB7
PSMB7.
Presentation: Purified
Presentation: Purified
Properties for PSMB7
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 10 µg |
| Synonyms | Macropain chain Z, Multicatalytic endopeptidase complex chain Z, Proteasome 20S beta 7, Proteasome subunit Z, Proteasome subunit beta type-7 |
| Presentation | Purified |
| Molecular weight | 27.6 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 80 % by SDS - PAGE |
| Background | PSMB7, also known as proteasome subunit beta type-7, is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i. |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| General Readings | Wang X., et al. (2007) Biochemistry. 46:3553-3565Rho J.H., et al. (2008) J. Proteome Res. 7:2959-2972 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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