Product Description for KPNA2 / Importin alpha-2
KPNA2 / Importin alpha-2.
Presentation: Purified
Presentation: Purified
Properties for KPNA2 / Importin alpha-2
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | Karyopherin alpha-2, RAG cohort protein 1, RCH1, SRP1-alpha |
| Presentation | Purified |
| Molecular weight | 60.5 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | Karyopherin alpha2 (KPNA2) is a member of the karyopherin alpha family. This protein plays a key role in the nuclear import of proteins with a classical nuclear localization signal (NLS). KPNA2 bound in vitro specifically and directly to substrates containing either a simple or bipartite NLS motif. It promoted docking of import substrates to the nuclear envelope and together with recombinant human Ran reconstituted complete nuclear protein import. |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| General Readings | Moroianu J., et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92:6532-6536Braem C.V., et al. (2002) J. Biol. Chem. 277:19673-19678 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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