Product Description for DUSP10 / MKP5
DUSP10 / MKP5.
Presentation: Purified
Presentation: Purified
Properties for DUSP10 / MKP5
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | Dual specificity protein phosphatase 10, MAP kinase phosphatase 5, MKP-5, Mitogen-activated protein kinase phosphatase 5 |
| Presentation | Purified |
| Molecular weight | 40.4 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 90 % by SDS - PAGE |
| Background | DUSP10 (Dual specificity protein phosphatase 10) belongs to the protein-tyrosine phosphatase family. Dual specificity protein phosphatases(DUSPs) inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. DUSP10 has been shown to interact with MAPK14 and MAPK8. When expressed in mammalian cells, DUSP10 blocks the enzymatic activation of MAP kinases with the selectivity p38 approximately JNK/SAPK >> ERK. |
| Concentration | 0.25mg/ml (determined by Bradford assay) |
| General Readings | Theodosiou A, et al. (1999) Oncogene. 18(50):6981-8.Jeong DG, et al. (2006) J Mol Biol. 360(5):946-55. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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