Product Description for HMG-CoA lyase / HMGCL
HMG-CoA lyase / HMGCL.
Presentation: Purified
Presentation: Purified
Properties for HMG-CoA lyase / HMGCL
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.5 mg |
| Synonyms | mitochondrial Hydroxymethylglutaryl-CoA lyase |
| Presentation | Purified |
| Molecular weight | 34.2 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 85 % by SDS - PAGE |
| Background | HMGCL, also known as hydroxymethylglutaryl-CoA lyase, is a mitochondrial matrix protein that belongs to the HMG-CoA lyase family. It exists as a homodimer and participates in leucine catabolism and ketogenesis, the hepatic synthesis of ketone bodies that, during fasting, provide a major source of energy for heart, brain and kidney. More specifically, it catalyzes the final step of these processes, the cleavage of 3-hydroxy-3-methylglutaryl-CoA to acetoacetic acid and acetyl-CoA. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Cardoso M.L. et al. (2004) Mol. Genet. Metab. 82: 334-338.Wang S.P et al. (1996) Genomics 33: 99-104. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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