LITAF (1-161, His-tag) - AR50770PU-N

Product Description for LITAF

LITAF.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.5 mg
Synonyms	LITAF, LPS-induced TNF-alpha factor, Lipopolysaccharide-induced tumor necrosis factor-alpha factor, PIG7, SIMPLE, Small integral membrane protein of lysosome/late endosome, p53-induced gene 7 protein
Presentation	Purified
Molecular weight	19.2 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q99732
Purity	> 85 % by SDS - PAGE
Background	Lipopolysaccharide-induced TNF-alpha factor, also known as LITAF, is a small integral membrane protein of lysosome/late endosome. LITAF mediates the expression of inflammatory cytokines such as TNF-alpha in Lipopolysaccharide-induced processes. LITAF binds to STAT6B, a member of the STAT6 family forming a complex on the TNF-alpha promoter that modulates TNF activity. High levels of expression of LITAF mRNA have been observed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Atucchi A., et al. (2006) Inflamm Bowel Dis. 13(1):120-121.Tang X., et al. (2005) Proc Natl Acad Sci USA. 102(14):5132-5137.
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human LITAF protein, fused to His-tag at N-terminus, was expressed in E.coli. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MSVPGPYQAA TGPSSAPSAP PSYEETVAVN SYYPTPPAPM PGPTTGLVTG PDGKGMNPPS YYTQPAPIPN NNPITVQTVY VQHPITFLDR PIQMCCPSCN KMIVSQLSYN AGALTWLSCG SLCLLGCIAG CCFIPFCVDA LQDVDHYCPN CRALLGTYKR L` Molecular weight: (181aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol Purity: >85% by SDS - PAGE State: Liquid purified protein Purified