RNF7 (1-113, His-tag) - AR51110PU-S

Product Description for RNF7

RNF7.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	CKBBP1, CKII beta-binding protein 1, RBX2, RING finger protein 7, RING-box protein 2, ROC2, Regulator of cullins 2, SAG, Sensitive to apoptosis gene protein
Presentation	Purified
Molecular weight	15.1 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q9UBF6
Purity	> 90 % by SDS - PAGE
Background	RNF7 is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Concentration	1.0 mg/ml (determined by Bradford assay)
General Readings	Swaroop M., et al. (2000). Oncogene 19:2855-2866
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human RNF7 protein, fused to His-tag at N-terminus, was expressed in E.coli . AA Sequence: `MGSSHHHHHH SSGLVPRGSH MGSMADVEDG EETCALASHS GSSGSKSGGD KMFSLKKWNA VAMWSWDVEC DTCAICRVQV MDACLRCQAE NKQEDCVVVW GECNHSFHNC CMSLWVKQNN RCPLCQQDWV VQRIGK` Molecular weight: (136aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea Purity: >90% by SDS - PAGE State: Liquid purified protein Purified