NDP (25-133, His-tag) - AR51114PU-S

Product Description for NDP

NDP.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	50 µg
Synonyms	EVR2, Norrie disease protein, Norrin
Presentation	Purified
Molecular weight	14.8 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q00604
Purity	> 80 % by SDS - PAGE
Background	Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation.
Concentration	0.5 mg/ml (determined by Bradford assay)
General Readings	Luhmann U F., et al. (2005) Invest Pothalmol Vis Sci. 46:3372-3382.Luhmann U F., et al. (2005) Genesis. 42:253-262
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS` Molecular weight: (132aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol Purity: >80% by SDS - PAGE State: Liquid purified protein Purified