Erythropoietin / EPO (28-193, His-tag) - AR51115PU-N

Product Description for Erythropoietin / EPO

Erythropoietin / EPO.
Presentation: Purified

Immunogen	Swiss Prot Num: P01588
Purity	> 80 % by SDS - PAGE
Background	Erythropoietin, also known as EPO, is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine hormone composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. Overexpression of EPO is associated with several pathophysiological conditions, such as polycythemias vera, which is caused by the EPO -independent growth of erythrocytic progenitors from abnormal stem cells.
Concentration	1 mg/ml (determined by Bradford assay)
General Readings	Jelkmann W., et al. (1992) Physiol Rev. 72:449-489.Takahashi T., et al. (1995) Blood. 85:106-114.
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human EPO protein, fused to His-tag at N-terminus, was expressed in E.coli. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MGSAPPRLIC DSRVLERYLL EAKEAENITT GCAEHCSLNE NITVPDTKVN FYAWKRMEVG QQAVEVWQGL ALLSEAVLRG QALLVNSSQP WEPLQLHVDK AVSGLRSLTT LLRALRAQKE AISPPDAASA APLRTITADT FRKLFRVYSN FLRGKLKLYT GEACRTGDR` Molecular weight: (189aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol Purity: >80% by SDS - PAGE State: Liquid purified protein Purified