Tyrosine-protein kinase JAK2 (1014-1132, His-tag) - AR51307PU-N

Product Description for Tyrosine-protein kinase JAK2

Tyrosine-protein kinase JAK2.
Presentation: Purified

Immunogen	Swiss Prot Num: O60674
Purity	> 95 % by SDS - PAGE
Background	JAK2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. Recombinant human Jak2 protein, fused to His-tag at N-terminus, was expressed in E.coli
Concentration	1.0 mg/ml (determined by Bradford assay)
General Readings	Bole-Feysot C, Goffin V,. et al. (1998). Endocr. Rev. 19 (3): 22568. doi:10.1210/er.19.3.225
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	AA Sequence: `MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE SPIFWYAPES LTESKFSVAS DVWSFGVVLY ELFTYIEKSK SPPAEFMRMI GNDKQGQMIV FHLIELLKNN GRLPRPDGCP DEIYMIMTEC WNNNVNQRPS FRDLALRVDQ IRDNMAG` Molecular weight: (157aa)
Format	Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea Purity: >95% by SDS - PAGE State: Liquid purified protein Purified