Product Description for WWTR1 / TAZ
WWTR1 / TAZ.
Presentation: Purified
Presentation: Purified
Properties for WWTR1 / TAZ
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1 |
| Presentation | Purified |
| Molecular weight | 46.5 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 85 % by SDS - PAGE |
| Background | WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Huang,W., et al. (2012) J. Biol. Chem. 287 (31), 26245-26253 Pan,J., et al. (2012) Oncol. Rep. 28 (1), 179-185 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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