Product Description for EGFL7
EGFL7.
Presentation: Purified
Presentation: Purified
Properties for EGFL7
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 2 µg |
| Synonyms | EGF like protein 7, EGF-like protein 7, Epidermal growth factor-like protein 7, MEGF7, Multiple EGF-like domains protein 7, Multiple epidermal growth factor-like domains protein 7, NOTCH4-like protein, PRO1449, UNQ187, VE-statin, Vascular endothelial statin, Zneu1 |
| Presentation | Purified |
| Molecular weight | 27.4 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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|---|---|
| Purity | > 98 % pure by SDS-PAGE gel and HPLC analyses |
| Background | EGF-L7 (Epidermal Growth Factor Like Protein 7, Multiple EGF Like Domains Protein 7, VE Statin) is a multi-domain protein containing two EGF like domains and one EMI domain. It is expressed almost exclusively in endothelial cells and functions to promote normal development of the vascular system, particularly tubulogenesis. EGF-L7 is capable of antagonistic binding to Notch receptors resulting in the inhibition of Notch signaling in HUVEC and neural stem cells. In research models inducing hypoxia and subsequent reoxygenation, (H/R), EGF-L7 can inhibit ICAM-1 expression and enhance the inhibition of NF-kappaB activation. Additionally, EGF-L7 can chemoattract endothelial cells and bind to the extracellular matrix. The overexpression of EGF-L7 is observed in various cancers, and is generally correlated with increased metastasis and a poor prognosis. |
| Storage | Prior to reconstitution store at 2-8°C for 6 months, at RT for one month or at -20°C to -80°C for longer. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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