Product Description for RAMP1
RAMP1.
Presentation: Purified
Presentation: Purified
Properties for RAMP1
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | CRLR activity-modifying protein 1, Calcitonin-receptor-like receptor activity-modifying protein 1, RAMP-1, Receptor activity-modifying protein 1 |
| Presentation | Purified |
| Molecular weight | 12.9 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 80 % by SDS - PAGE |
| Background | RAMP is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| General Readings | Kusano S, Kukimoto-Niino M, et al. (2008). Protein Sci. 17(11):1907-14. Héroux M, Hogue M, et al. (2007). J Biol Chem. 282(43):31610-20. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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