Product Description for SERPINC1 / Antithrombin-III
SERPINC1 / Antithrombin-III.
Presentation: Purified
Presentation: Purified
Properties for SERPINC1 / Antithrombin-III
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | AT3, ATIII, Serpin C1 |
| Presentation | Purified |
| Molecular weight | 51.4 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 85 % by SDS - PAGE |
| Background | Antithrombin-III precursor, also known as SERPINC1, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The inhibitory activity of SERPINC1 is amplified in the presence of heparin. SERPINC1 inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Yeung P K., et al. (2000) IDrugs. 37: 669-673. Okajima K., et al. (1995) Am J Hematol. 48: 12-18. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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