Product Description for CD162 / PSGL1
CD162 / PSGL1.
Presentation: Purified
Presentation: Purified
Properties for CD162 / PSGL1
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 20 µg |
| Synonyms | P-selectin glycoprotein ligand 1, PSGL-1, SELPLG, Selectin P ligand |
| Presentation | Purified |
| Molecular weight | 10.9 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 80 % by SDS - PAGE |
| Background | SELPLG is a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants. |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| General Readings | Stübke K, Wicklein D, et al. (2012). Cancer Lett. 321(1):89-99. Gong L, Cai Y, et al. (2012). Pathol Oncol Res. 18(4):989-96. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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