Product Description for MCM7
MCM7.
Presentation: Purified
Presentation: Purified
Properties for MCM7
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | CDC47, CDC47 homolog, DNA replication licensing factor MCM7, MCM2, P1.1-MCM3, minichromosome maintenance complex component 7 |
| Presentation | Purified |
| Molecular weight | 48.6 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 85 % by SDS - PAGE |
| Background | MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Zhou,Y.M., et al. (2012) Liver Int. 32 (10), 1505-1509 Liu,Y.Z., et al. (2012) Lung Cancer 77 (1), 176-182 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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