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discontinued

SM286R CD54 / ICAM1 antibody

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Quick Overview

Mouse anti Rat CD54 / ICAM1 1A29

SM286R

Product Description for CD54 / ICAM1

Mouse anti Rat CD54 / ICAM1 1A29.
Presentation: PE
Product is tested for Flow Cytometry.

Properties for CD54 / ICAM1

Product Category Primary Antibodies
Quantity 100 Tests
Synonyms ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor
Presentation PE
Reactivity Rt
Applications F
Clonality Monoclonal
Clone 1A29
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q00238
Immunogen:
Rat Ax cells (a HEV derived cell line). Spleen cells from immunised BALB/c mice were fused with cells from the PAI mouse myeloma cell line.
GeneID:
25464
Isotype control SM20R (for use in rat samples)
Application Flow cytometry.
Background CD54 is a 90kD adhesion molecule belonging to the immunoglobulin superfamily. CD54 is a cell surface ligand of the lymphocyte integrin, LFA-1 and is known to play an important role in various cell-cell interactions in the immune system.
General Readings
  1. Tamatani T, Miyasaka M. Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int Immunol. 1990;2(2):165-71. PubMed PMID: 2088483.
  2. Tamatani T, Kotani M, Tanaka T, Miyasaka M. Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells. Eur J Immunol. 1991 Mar;21(3):855-8. PubMed PMID: 1672652.
  3. Etienne-Manneville S, Manneville JB, Adamson P, Wilbourn B, Greenwood J, Couraud PO. ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. J Immunol. 2000 Sep 15;165(6):3375-83. PubMed PMID: 10975856.
Storage Prior to and following reconstitution store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Shelf life: 6 month from despatch.
Format
Label:
R. Phycoerythrin (RPE)
PE
Purification:
Affinity chromatography on Protein G
Buffer System:
PBS, pH 7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
State:
Lyophilized purified IgG
Reconstitution:
Restore with 1 ml distilled water
Specificity
Specificity:
This antibody recognises the CD54 cell surface antigen, also known as intercellular adhesion molecule-1 (ICAM-1). Recent studies suggest that cross-linking of ICAM-1 using clone 1A29 induces calcium signalling. Functionally 1A29 inhibits homotypic aggregation of PHA blasts. We recommend the use of SM286LE for use in functional studies.
Species:
Rat.
Gene ID 25464

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