AM33020PU-N PTPRT antibody

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0.1 mg / €690.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human, Porcine, Rat PTPRT 3D7

AM33020PU-N

Product Description for PTPRT

Mouse anti Human, Porcine, Rat PTPRT 3D7.
Presentation: Purified
Product is tested for Western blot / Immunoblot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunoprecipitation.

Properties for PTPRT

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms KIAA0283, KIAA0283, PTP rho, R-PTP-T, RPTP-rho, Receptor-type tyrosine-protein phosphatase T, Receptor-type tyrosine-protein phosphatase rho
Presentation Purified
Reactivity Hu, Por, Rt
Applications F, ICC/IF, IP, WB
Clonality Monoclonal
Clone 3D7
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O14522
Immunogen:
This antibody has been derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with ExG protein, secreted by NIH-3T3 transfected cells and purified with glutahione beads.
The cells have been transfected using a fusion construct, termed ExG, encoding the entire ectodomain of the Human RPTPµ molecule (aa 1-742), fused COOH terminally to GST.
GeneID:
11122
Isotype control AM03096PU-N
Application Western blot.
Immunoprecipitation.
Immunofluorescence.
Flow Cytometry.
Background Receptor-like protein tyrosine phosphatases (RPTPs) represent a new family of transmembrane proteins that are thought to transduce external signals by dephosphorylating phosphotyrosine residues on intracellular substrates. RPTPµ is a prototypic receptor-like protein-tyrosine phosphatase (RPTP) that mediates homotypic cell-cell interactions.
Intracellularly, RPTPµ consists of a relatively large juxtamembrane region (about 150 amino acids) and two conserved phosphatase domains. As in most RPTPs, the first (membrane-proximal) PTP domain of RPTPµ is catalytically active, whereas its second (C-terminal) domain is inactive. RPTPµ is involved in cell-cell adhesion through homophilic interactions and may also play a key role in signal transduction and growth control.
Concentration 1.0 mg/ml
General Readings
  1. Gerben C. M. Zondag, Albert B. Reynolds§, and Wouter H. Moolenaar. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 275, No. 15, Issue of April 14, pp. 11264–11269, 2000.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS
Preservatives:
0.09% Sodium Azide
State:
Liquid purified IgG fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, Rat, Swine.
Specificity
Specificity:
Monoclonal antibodies 3G4 and 3D7 have been directed against the extracellular domain of RPTPµ.

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