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AP33204SU-N Junction plakoglobin (N-term, 5-21) antibody

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0.1 ml / €380.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Quick Overview

Guinea Pig anti Human, Mouse Junction plakoglobin

AP33204SU-N

Product Description for Junction plakoglobin

Guinea Pig anti Human, Mouse Junction plakoglobin.
Properties: (N-term, 5-21)
Presentation: Serum
Product is tested for Frozen Sections, Paraffin Sections, Western blot / Immunoblot.

Properties for Junction plakoglobin

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms CTNNG, Catenin gamma, DP3, Desmoplakin III, Desmoplakin-3, JUP
Presentation Serum
Reactivity Hu, Ms
Applications C, P, WB
Clonality Polyclonal
Host Guinea Pig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P14923
Immunogen:
Synthetic N-terminus of Human Plakoglobin (aa 5-21), identical to gamma-Catenin
GeneID:
3728
Property N-term, 5-21
Application Immunoblotting (Western blot): 1/2000.
Immunohistochemistry on Frozen Sections: 1/100.
Immunohistochemistry on Paraffin Sections: 1/50 (after microwave treatment).
Cytological Material.
Incubation Time: 1 h at RT extended with paraffin sections.
Background Gamma Catenin is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of gamma Catenin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. It is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
General Readings
  1. Saffitz JE. The pathobiology of arrhythmogenic cardiomyopathy. Annu Rev Pathol. 2011;6:299-321. doi: 10.1146/annurev-pathol-011110-130151. PubMed PMID: 21073337.
  2. Huang H, Asimaki A, Lo D, McKenna W, Saffitz J. Disparate effects of different mutations in plakoglobin on cell mechanical behavior. Cell Motil Cytoskeleton. 2008 Dec;65(12):964-78. doi: 10.1002/cm.20319. PubMed PMID: 18937352. (Free PMC Article available, 8 images available)
  3. Kolligs FT, Kolligs B, Hajra KM, Hu G, Tani M, Cho KR, et al. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev. 2000 Jun 1;14(11):1319-31. PubMed PMID: 10837025. (Free PMC Article available, 7 images available)
  4. Behrens J. Cadherins and catenins: role in signal transduction and tumor progression. Cancer Metastasis Rev. 1999;18(1):15-30. PubMed PMID: 10505543.
  5. Palka HL, Green KJ. Roles of plakoglobin end domains in desmosome assembly. J Cell Sci. 1997 Oct;110 ( Pt 19):2359-71. PubMed PMID: 9410875.
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Preservatives:
0.09% Sodium Azide
State:
Liquid prediluted stabilized antiserum
Serum
Species Reactivity
Species reactivity (tested):
Human, Mouse.
Specificity
Specificity:
Specific detection of Mr 83 000 Plakoglobin, "band 5" polypeptide of intercellular adhering junctions (also described as Gamma-Catenin).
Excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis).
Especially useful for studying plakoglobin mutations in cardiomyopathies (e.g. ARVC, see References below).

Accessory Products

Proteins and/or Positive Controls

Proteins for Junction plakoglobin (3 products)

Catalog No. Species Pres. Purity   Source  

Junction plakoglobin (transcript variant 1)
Junction plakoglobin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. 		HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

Junction plakoglobin
Junction plakoglobin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Junction plakoglobin
Junction plakoglobin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for Junction plakoglobin (4 products)

Catalog No. Species Pres. Purity   Source  

gamma Catenin Lysate
Western Blot: gamma Catenin Lysate [NBL1-12118] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for JUP
  Novus Biologicals Inc.

JUP overexpression lysate
JUP overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

JUP overexpression lysate
JUP overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

JUP overexpression lysate
JUP overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.

Recommended Secondary Antibodies for Junction plakoglobin (8 products)

Catalog No. Host Clone/Iso. Pres.   React. Applications  

Guinea pig IgG (H+L chain) antibody
Guinea pig IgG (H+L chain) antibody Rabbit AP
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain) antibody
Guinea pig IgG (H+L chain) antibody Rabbit FITC
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain) antibody
Guinea pig IgG (H+L chain) antibody Rabbit HRP GP E, P, WB
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain) antibody
Guinea pig IgG (H+L chain) antibody Rabbit Aff - Purified
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain) antibody
Guinea pig IgG (H+L chain) antibody Rabbit TRITC
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain, adsorbed) antibody
Guinea pig IgG (H+L chain, adsorbed) antibody Goat Cy2
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain), adsorbed antibody
Guinea pig IgG (H+L chain), adsorbed antibody Goat Cy3
    OriGene Technologies GmbH

Guinea pig IgG (H+L chain), adsorbed antibody
Guinea pig IgG (H+L chain), adsorbed antibody Goat Cy5
    OriGene Technologies GmbH
Click here to see all secondary antibodies for Junction plakoglobin
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