Product Description for RPRD1B
RPRD1B.
Presentation: Purified
Presentation: Purified
Properties for RPRD1B
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | C20orf77, CREPT, Cell cycle-related and expression-elevated protein in tumor, Regulation of nuclear pre-mRNA domain-containing protein 1B, chromosome 20 open reading frame 77 |
| Presentation | Purified |
| Molecular weight | 39.3 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
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| Purity | > 90 % by SDS - PAGE |
| Background | RPRD1B also known as regulation of nuclear pre-mRNA domain-containing protein 1B. This protein interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. It promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. It prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. It also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. It promotes cell proliferation. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Lu D., et al. (2012) Cancer Cell 21:92-104 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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