Granzyme H (GZMH) (20-246, His-tag) - AR51860PU-S

Product Description for Granzyme H (GZMH)

Granzyme H (GZMH).
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	20 µg
Synonyms	CCP-X, CGL2, CSP-C, CTSGL2, Cathepsin G-like 2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C
Presentation	Purified
Molecular weight	27.5 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: P20718
Purity	> 85 % by SDS - PAGE
Background	GZMH also known as Granzyme H is essential for HBV eradication. The HBx protein (HBx), required for the replication of HBV, is cleaved at Met(79) by GZMH. GZMH inhibitor can abolish GZNH- and lymphokine-activated killer cell-mediated HBx degradation and HBV clearance. An HBx-deficient HBV is resistant to GzmH- and lymphokine-activated killer cell-mediated viral clearance.
Concentration	0.25 mg/ml (determined by Bradford assay)
General Readings	Ewen CL., et al. (2013) Mol. Immunol. 54 (3-4), 309-318 Wang L., et al. (2012) J. Immunol. 190 (3), 1319-1330
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	Description: Recombinant human GZMH, fused to His-tag at N-terminus, was expressed in E.coli. AA Sequence: `MGSSHHHHHH SSGLVPRGSH MEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRL` Molecular weight: (248aa)
Format	Buffer System: 20 mM Tris 8.0 containing 10% glycerol. Purity: >85% by SDS - PAGE State: Liquid purified protein Purified