Product Description for SPI1 / PU.1
SPI1 / PU.1.
Presentation: Purified
Presentation: Purified
Properties for SPI1 / PU.1
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | 31 kDa transforming protein, SFPI1, SPI-1 proto-oncogene, Transcription factor PU.1, spleen focus forming virus (SFFV) proviral integration oncogene spi1 |
| Presentation | Purified |
| Molecular weight | 33.6 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 85 % by SDS - PAGE |
| Background | SPI1 also known as transcription factor Pu.1, is a protein that in humans is encoded by the SPI1 gene. This protein have ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the Pu-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. It can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| General Readings | Ray D, Culine S, et al. (1990). Oncogene. 5(5):663-8.Hallier M, Tavitian A, et al. (1996). J Biol Chem. 271(19):11177-81. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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