AR51798PU-S Granzyme B (GZMB) (21-247, His-tag)

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0.1 mg / €320.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Granzyme B (GZMB)

Product Description for Granzyme B (GZMB)

Granzyme B (GZMB).
Presentation: Purified

Properties for Granzyme B (GZMB)

Product Category Proteins & Growth Factors
Quantity 0.1 mg
Synonyms CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Cathepsin G-like 1, Cytotoxic T-lymphocyte proteinase 2, Fragmentin-2, GRB, Granzyme-2, Lymphocyte protease, SECT, T-cell serine protease 1-3E
Presentation Purified
Molecular weight 27.8 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P10144
Purity > 85 % by SDS - PAGE
Background GZMB also known as granzyme B is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens.
General Readings
  1. Xu W, Narayanan P, Kang N, Clayton S, Ohne Y, Shi P, et al. Human plasma cells express granzyme B. Eur J Immunol. 2014 Jan;44(1):275-84. doi: 10.1002/eji.201343711. Epub 2013 Oct 20. PubMed PMID: 24114594.
  2. Fritsch K, Finke J, Grüllich C. Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9. Ann Hematol. 2013 Dec;92(12):1603-9. doi: 10.1007/s00277-013-1846-6. Epub 2013 Jul 28. PubMed PMID: 23892923.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human GZMB, fused to His-tag at N-terminus, was expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MIIGGHEAKP HSRPYMAYLM IWDQKSLKRC GGFLIQDDFV LTAAHCWGSS INVTLGAHNI KEQEPTQQFI PVKRPIPHPA YNPKNFSNDI MLLQLERKAK RTRAVQPLRL PSNKAQVKPG QTCSVAGWGQ TAPLGKHSHT LQEVKMTVQE DRKCESDLRH YYDSTIELCV GDPEIKKTSF KGDSGGPLVC NKVAQGIVSY GRNNGMPPRA CTKVSSFVHW IKKTMKRY
Molecular weight:
(248aa)
Format
Buffer System:
20 mM Tris 8.0 containing 10% glycerol.
Purity:
>85% by SDS - PAGE
State:
Liquid purified protein
Purified
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