Product Description for CD130 / IL6ST
CD130 / IL6ST.
Presentation: Purified
Presentation: Purified
Properties for CD130 / IL6ST
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 0.25 mg |
| Synonyms | IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta |
| Presentation | Purified |
| Molecular weight | 67.7 kDa |
| Source | Insect cells |
| Species (Protein) | Mouse |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 95 % by SDS - PAGE |
| Background | IL6st, also known as interleukin-6 receptor subunit beta, is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for sigl transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kises to elicit an intracellular sigl following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion. Recombint mouse IL6st, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventiol chromatography techniques. |
| Concentration | 1.0 mg/ml (determined by absorbance at 280nm) |
| General Readings | Saito M., et al. (1992) J Immunol. 148: 4066-4071.Murakami M., et al. (1993) Science. 260:1808-1810. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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