Product Description for CNTF
CNTF.
Presentation: Purified
Presentation: Purified
Properties for CNTF
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | Ciliary Neurotrophic Factor |
| Presentation | Purified |
| Molecular weight | 25.2 kDa |
| Source | E. coli |
| Species (Protein) | Rat |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % by SDS-PAGE |
| Background | CNTF also known as ciliary neurotrphic factor is a survival factor for various neurol cell types. CNTF is highly conserved across species and exhibits cross-species bioactivity. CNTF is a 25 kDa polypeptide that was origilly isolated as a target-derived survival factor of parasympathetic ciliary ganglion neurons. Binding of CNTF to CNTF receptor triggers heterodimerization of gp130 and LIFR, forming an active trimeric receptor complex and activates the downstream sigling pathway. |
| Concentration | 0.5 mg/ml (determined by bradford assay) |
| General Readings | Linker R., et al. (2009) Crit Rev Immunol. 29(1):43-68. Stahl N., et al. (1994) J Neurobiol. 25(11):1454-66. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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