Product Description for CRTAM
CRTAM.
Presentation: Purified
Presentation: Purified
Properties for CRTAM
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 50 µg |
| Synonyms | Class-I MHC-restricted T-cell-associated molecule, Cytotoxic and regulatory T-cell molecule |
| Presentation | Purified |
| Molecular weight | 31.0 kDa |
| Source | Insect cells |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | CRTAM, also known as cytotoxic and regulatory T-cell molecule, is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. It is a molecule involved in epithelial cell adhesion. This protein interacts with CADM1 promotes tural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Recombint human CRTAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventiol chromatography techniques. |
| Concentration | 1.0 mg/ml (determined by absorbance at 280nm) |
| General Readings | Kennedy J., et al. (2000) J. Leukoc. Biol. 67:725-734.Boles K.S., et al. (2005) Blood 106:779-786. |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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