MESDC2 (30-224, His-tag) - AR52012PU-N

Product Description for MESDC2

MESDC2.
Presentation: Purified

Product Category	Proteins & Growth Factors
Quantity	0.1 mg
Synonyms	KIAA0081, MESDC2, Mesoderm development candidate 2, UNQ1911/PRO4369
Presentation	Purified
Molecular weight	24.4 kDa
Source	E. coli
Species (Protein)	Mouse
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	OriGene Technologies GmbH
Material safety datasheet	MSDS for Proteins (de)

Immunogen	Swiss Prot Num: Q9ERE7
Purity	> 90 % by SDS - PAGE
Background	MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Recombint mouse MESDC2, fused to His-tag at N-terminus was expressed in E.coli and purified by using conventiol chromatography techniques.
Concentration	1.0 mg/ml (determined by absorbance at 280nm)
General Readings	Lu W., et al. (2010) Biochemistry. 49(22): 4635-43.Hoshi T., et al. (2013) FEBS Lett. 587(23): 3749-54.
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	AA Sequence: `MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRRE이` Molecular weight: (218aa)
Format	Buffer System: Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. Purity: >90% by SDS - PAGE State: Liquid purified protein Purified