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Home » Alpha-2C adrenergic receptor / ADRA2C
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TA326435 Alpha-2C adrenergic receptor / ADRA2C (442- 462, Cytopl. Dom.) antibody

Mouse monoclonal Alpha-2C Adrenergic Receptor Antibody

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Mouse anti Human, Mouse Alpha-2C adrenergic receptor / ADRA2C S330A-51

TA326435

Product Description for Alpha-2C adrenergic receptor / ADRA2C

Mouse anti Human, Mouse Alpha-2C adrenergic receptor / ADRA2C S330A-51.
Properties: (442- 462, Cytopl. Dom.)
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Alpha-2C adrenergic receptor / ADRA2C

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms ADRA2L2, ADRA2RL2, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor
Presentation Purified
Reactivity Hu, Ms
Applications ICC/IF, WB
Clonality Monoclonal
Clone S330A-51
Host Mouse
Isotype IgG2a
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P18825
Immunogen:
Fusion protein, amino acids 442- 462 (cytoplasmic, C-terminus) of human Alpha-2C adrenergic receptor
AA Sequence:
QDFRRSFKHILFRRRRRGFRQ
GeneID:
152
Property 442- 462, Cytopl. Dom.
Isotype control AM03096PU-N
Application Immunocytochemistry.
Western Blot: 1/1000.
1 μg/ml of this antibody was sufficient for detection of Alpha-2C adrenergic receptor in 20μg of COS cells transiently transfected with HA-tagged Alpha-2C membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG-HRP as the secondary antibody.
Background The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C Adrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.
Concentration 1.0 mg/ml
General Readings
  1. Filipeanu CM, de Vries R, Danser AH, Kapusta DR. Modulation of α(2C) adrenergic receptor temperature-sensitive trafficking by HSP90. Biochim Biophys Acta. 2011 Feb;1813(2):346-57. doi: 10.1016/j.bbamcr.2010.11.020. Epub 2010 Dec 9. PubMed PMID: 21145921. (Free PMC Article available, 9 images available)
  2. Powe DG, Voss MJ, Habashy HO, Zänker KS, Green AR, Ellis IO, et al. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast Cancer Res Treat. 2011 Nov;130(2):457-63. doi: 10.1007/s10549-011-1371-z. Epub 2011 Feb 6. PubMed PMID: 21298476.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Protein G chromatography
Buffer System:
PBS pH 7.4, 50% Glycerol
Preservatives:
0.09% Sodium azide
State:
Liquid purified IgG fraction
Purified
Specificity
Specificity:
This antibody detects Alpha-2C adrenergic receptor (aa442-462);
~ 50 kDa or larger (possibly due to dimerization).
Does not cross-react with other adrenergic receptors.
Species:
Human, Mouse.

Accessory Products

Proteins and/or Positive Controls

Positive controls for Alpha-2C adrenergic receptor / ADRA2C (1 products)

Catalog No. Species Pres. Purity   Source  

Alpha 2c Adrenergic Receptor Lysate
Western Blot: Alpha 2c Adrenergic Receptor Lysate [NBL1-07358] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for ADRA2C Protein
  Novus Biologicals Inc.

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