Product Description for Kelch-like protein 12
Rabbit anti Bovine, Canine, Equine, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat, Zebrafish Kelch-like protein 12.
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Presentation: Purified
Product is tested for Western blot / Immunoblot.
Properties for Kelch-like protein 12
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 0.1 ml |
| Synonyms | C3IP1, CUL3-interacting protein 1, KLHL12 |
| Presentation | Purified |
| Reactivity | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze |
| Applications | WB |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Shipping to | Europe, USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies, Inc. |
Datasheet Extract
| Immunogen |
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|---|---|
| Application | WB |
| Background | KLHL12 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt sigling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitition of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt sigling pathway by mediating ubiquitition and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitition of DRD4, without leading to degradation of DRD4. |
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Accessory Products
Proteins and/or Positive Controls
Proteins for Kelch-like protein 12 (5 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00059349-P01 |
Kelch-like protein 12 |
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|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00059349-P01-10 |
Kelch-like protein 12 |
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|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00059349-P01-25 |
Kelch-like protein 12 |
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|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| 10-288-22280F |
Kelch-like protein 12 |
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|
|
Human | Purified | 95 % | E. coli | |||
| GenWay Biotech Inc. | |||||||
| 10-288-22280F-50 |
Kelch-like protein 12 |
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|
|
Human | Purified | 95 % | E. coli | |||
| GenWay Biotech Inc. | |||||||
Positive controls for Kelch-like protein 12 (2 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-12333 |
C3IP1 Lysate |
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![Western Blot: KLHL12/C3IP1 Lysate [NBL1-12333] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for KLHL12/C3IP1](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/C3IP1%20Lysate-Western%20Blot-NBL1-12333-img0001.jpg) |
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| Novus Biologicals Inc. | |||||||
| H00059349-T01 |
KLHL12 293T Cell Transient Overexpression Lysate(Denatured) |
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| Abnova Taiwan Corp. | |||||||
Recommended Secondary Antibodies for Kelch-like protein 12 (9 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1364AP |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | AP | Rb | E, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364B |
Rabbit IgG (H+L chain) antibody |
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|
|
Goat | Biotin | Rb | E, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364F |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | FITC | Rb | E, ICC/IF, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364HRP |
Rabbit IgG (H+L chain) antibody |
||||||
|
Goat | HRP | Rb | E, P, WB | |||
| OriGene Technologies GmbH | |||||||
| R1364T |
Rabbit IgG (H+L chain) antibody |
||||||
|
|
Goat | TRITC | Rb | E, F, ICC/IF | |||
| OriGene Technologies GmbH | |||||||
| R1427R |
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody |
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|
|
Donkey | PE | Rb | F | |||
| OriGene Technologies GmbH | |||||||
| R1458C2 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1458C3 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1458C5 |
Rabbit IgG (H+L chain, adsorbed) antibody |
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|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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