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BM2543 CD41-CD61 Complex antibody

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0.2 mg / €740.00
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Mouse anti Human CD41-CD61 Complex P2

BM2543

Product Description for CD41-CD61 Complex

Mouse anti Human CD41-CD61 Complex P2.
Presentation: Azide Free
Product is tested for Frozen Sections, Enzyme Immunoassay, Functional assay, Immunoprecipitation, Flow Cytometry.

Properties for CD41-CD61 Complex

Product Category Primary Antibodies
Quantity 0.2 mg
Synonyms CD41, CD61, GP2B, GP3A, GPIIb, GPIIb-IIIa, GPalpha IIb, ITGA2B, ITGAB, ITGB3, Integrin alpha-IIb, Integrin beta-3, Platelet membrane glycoprotein IIb
Presentation Azide Free
Reactivity Hu
Applications C, E, F, FN, IP
Clonality Monoclonal
Clone P2
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Human platelets
Application ELISA.
Immunoprecipitation.
Functional Assays. 
Fluorescence Microscopy or Flow Cytometry: 2 µg / 5x106 platelets/test.
Immunohistochemistry (Only suitable on Frozen Sections or Cell Smears): 1/50-1/100. 
Not recommended for use in Western blot.
Background Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.
Concentration 0.2 mg/ml (prior to lyophilization)
Product Citations
Purchased from Acris:
FITC conjugated antibody is cited in:
  1. Fröbel J, Cadeddu RP, Hartwig S, Bruns I, Wilk CM, Kündgen A, et al. Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol Cell Proteomics. 2013 May;12(5):1272-80. doi: 10.1074/mcp.M112.023168. Epub 2013 Feb 4. PubMed PMID: 23382103. (Free PMC Article available, 8 images available)
General Readings
  1. McGregor JL, Brochier J, Wild F, Follea G, Trzeciak MC, James E, et al. Monoclonal antibodies against platelet membrane glycoproteins. Characterization and effect on platelet function. Eur J Biochem. 1983 Mar 15;131(2):427-36. PubMed PMID: 6832159.
  2. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood. 1988 Apr;71(4):831-43. PubMed PMID: 2833328.
  3. This antibody was studied at the Human Leucocyte Workshop in Oxford (1986).
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term. 
The addition of 0.09% (w/v) Sodium Azide is recommended for storage of the reconstituted form for up to one month at 2-8°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
PBS buffer
Preservatives:
None
Stabilizers:
1 mg/ml BSA
State:
Lyophilized purified Ig fraction
Azide Free
Reconstitution:
Restore with 1 ml distilled water.
Specificity
Specificity:
Reacts with gpIIb in the intact complex with gpIIIa, but not with IIb or IIIa, separately.
Inhibits platelet aggregation induced by thrombin, collagen and ADP.
The Molecular weight of the recognized antigen is 135kDa/95kDa.

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