Product Description for TP53 / p53
Mouse anti Human, Mouse, Rat TP53 / p53 C6A5.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.
Properties for TP53 / p53
| Product Category | Primary Antibodies |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53 |
| Presentation | Purified |
| Reactivity | Hu, Ms, Rt |
| Applications | ICC/IF, IP, P, WB |
| Clonality | Monoclonal |
| Clone | C6A5 |
| Host | Mouse |
| Isotype | IgG1 |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Monoclonal Antibodies (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Isotype control | AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples) |
| Add. information | Mol. Weight: 53 kDa |
| Application | Western Blot: 0.5-4 µg/ml. Immunoprecipitation: 4-8 µg/ml. Immunohistochemistry: 4-8 µg/ml. Immunocytochemistry: 4-8 µg/ml. |
| Background | p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression through the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis. |
| Concentration | 0.5 mg/ml |
| Storage | Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Format |
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| Species Reactivity |
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| Specificity |
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| Gene ID | 7157 |
Accessory Products
Proteins and/or Positive Controls
Proteins for TP53 / p53 (23 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| TP300003 |
TP53 / p53 (transcript variant 1) |
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|
Human |
> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
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| OriGene Technologies, Inc. | |||||||
| TP325502 |
TP53 / p53 (transcript variant 3) |
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|
Human |
> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|||
| OriGene Technologies, Inc. | |||||||
| TP325604 |
TP53 / p53 (transcript variant 2) |
||||||
|
Human |
> 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|||
| OriGene Technologies, Inc. | |||||||
| TP701001 |
TP53 / p53 (transcript variant 1) |
||||||
|
Human |
> 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|||
| OriGene Technologies, Inc. | |||||||
| TP710022 |
TP53 / p53 (full length, C-term DDK tag, transcript variant 1) |
||||||
|
Human |
> 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
SF9 cells |
20 µg /
€411.00
|
|||
| OriGene Technologies, Inc. | |||||||
| AR10316PU-L |
TP53 / p53 |
||||||
|
Human | Purified | > 95.0% as determined by SDS-PAGE | E. coli | |||
| OriGene Technologies GmbH | |||||||
| AR10316PU-N |
TP53 / p53 |
||||||
|
|
Human | Purified | > 95.0% as determined by SDS-PAGE | E. coli | |||
| OriGene Technologies GmbH | |||||||
| AR10316PU-S |
TP53 / p53 |
||||||
|
|
Human | Purified | > 95.0% as determined by SDS-PAGE | E. coli | |||
| OriGene Technologies GmbH | |||||||
| PA1366 |
TP53 / p53 (Mutant) |
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|
|
Human | Purified | > 90 % | E. coli | |||
| OriGene Technologies GmbH | |||||||
| PA1366X |
TP53 / p53 (Mutant) |
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|
|
Human | Purified | > 90 % | E. coli | |||
| OriGene Technologies GmbH | |||||||
| PA1366XC |
TP53 / p53 (Mutant) |
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|
|
Human | Purified | > 90 % | E. coli | |||
| OriGene Technologies GmbH | |||||||
| PA1368 |
TP53 / p53 |
||||||
|
|
Human | Purified | > 95 % pure as determined by SDS-PAGE. | E. coli | |||
| OriGene Technologies GmbH | |||||||
| PA1368X |
TP53 / p53 |
||||||
|
|
Human | Purified | > 95 % pure as determined by SDS-PAGE. | E. coli | |||
| OriGene Technologies GmbH | |||||||
| PA1368XC |
TP53 / p53 |
||||||
|
|
Human | Purified | > 95 % pure as determined by SDS-PAGE. | E. coli | |||
| OriGene Technologies GmbH | |||||||
| H00007157-P01 |
TP53 / p53 |
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|
|
Human | ||||||
| Abnova Taiwan Corp. | |||||||
| H00007157-P01-10 |
TP53 / p53 |
||||||
|
|
Human | in vitro transl. | |||||
| Abnova Taiwan Corp. | |||||||
| H00007157-P01-25 |
TP53 / p53 |
||||||
|
|
Human | in vitro transl. | |||||
| Abnova Taiwan Corp. | |||||||
| H00007157-P02 |
TP53 / p53 |
||||||
|
|
Human | Purified | |||||
| Abnova Taiwan Corp. | |||||||
| H00007157-P02-10 |
TP53 / p53 |
||||||
|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00007157-P02-25 |
TP53 / p53 |
||||||
|
|
Human | Purified | 12.5% SDS-PAGE Stained with Coomassie Blue. | ||||
| Abnova Taiwan Corp. | |||||||
| H00007157-Q01-10 |
TP53 / p53 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| H00007157-Q01-25 |
TP53 / p53 |
||||||
|
|
Human | 12.5% SDS-PAGE Stained with Coomassie Blue. | in vitro transl. | ||||
| Abnova Taiwan Corp. | |||||||
| P5316-R-20 |
TP53 / p53 (Wild type) |
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|
|
Human | Purified | > 95 % | E. coli | |||
| Alpha Diagnostic Intl. Inc. | |||||||
Positive controls for TP53 / p53 (3 products)
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| NBL1-17203 |
p53 Lysate |
||||||
![Western Blot: p53 Lysate [NBL1-17203] - Western Blot experiments.
Left-Control; Right -Over-expression Lysate for TP53](https://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/p53%20Lysate-Western%20Blot-NBL1-17203-img0001.jpg) |
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| Novus Biologicals Inc. | |||||||
| H00007157-T01 |
TP53 293T Cell Transient Overexpression Lysate(Denatured) |
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|
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| Abnova Taiwan Corp. | |||||||
| H00007157-T02 |
TP53 293T Cell Transient Overexpression Lysate(Denatured) |
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|
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| Abnova Taiwan Corp. | |||||||
Recommended Secondary Antibodies for TP53 / p53 (11 products)
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| R1253AP |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | AP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253B |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Biotin | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253F |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | FITC | E, ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1253HRP |
Mouse IgG (H+L chain) antibody |
||||||
|
Rabbit | HRP | C, E, WB | ||||
| OriGene Technologies GmbH | |||||||
| R1253TR |
Mouse IgG (H+L chain) antibody |
||||||
|
|
Rabbit | Texas Red | ICC/IF | ||||
| OriGene Technologies GmbH | |||||||
| R1403R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
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|
|
Rabbit | PE | F | ||||
| OriGene Technologies GmbH | |||||||
| R1405R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Goat | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1455R |
Mouse IgG (H+L chain), F(ab)2 Fragment, adsorbed antibody |
||||||
|
|
Donkey | PE | |||||
| OriGene Technologies GmbH | |||||||
| R1457C2 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy2 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C3 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy3 | |||||
| OriGene Technologies GmbH | |||||||
| R1457C5 |
Mouse IgG (H+L chain), adsorbed antibody |
||||||
|
|
Goat | Cy5 | |||||
| OriGene Technologies GmbH | |||||||
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