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AP02513PU-N Merlin pSer518 antibody

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0.1 mg / €300.00
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Rabbit anti Human, Mouse, Rat Merlin

AP02513PU-N

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  • AP02513PU-N

Product Description for Merlin

Rabbit anti Human, Mouse, Rat Merlin.
Properties: pSer518
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Merlin

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Moesin-ezrin-radixin-like protein, NF2, Neurofibromin-2, SCH, Schwannomerlin, Schwannomerlin, Schwannomin, Schwannomin
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P35240
Immunogen:
The antiserum was produced against synthesized phosphopeptide derived from human Merlin around the phosphorylation site of serine 518 (R-L-SP-M-E).
GeneID:
4771
Property pSer518
Application Western Blot: 1/500-1/1000.
Immunofluorescence: 1/100-1/200.
Background Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility.

Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.
Concentration 1.0 mg/ml
General Readings
  1. Guang-Hui Xiao, et,al. (2005) Mol. Cell. Biol ; 25: 2384 - 2394.
  2. Hi-Su Yang, et,al. (2006) Cancer Res ; 66: 2708 - 2715.
  3. R Bohni, et,al. (1994) J. Biol. Chem ; 269: 14541 - 14545.
  4. Adam J. Ratner, et,al. (2001) J. Biol. Chem ; 276: 19267 - 19275.
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Buffer System:
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State:
Liquid purified Ig fraction.
Aff - Purified
Specificity
Specificity:
AP02513PU antibody detects endogenous levels of Merlin only when
phosphorylated at Serine 518.
Species:
Human, Mouse and Rat.
Gene ID 4771

Accessory Products

Proteins and/or Positive Controls

Proteins for Merlin (2 products)

Catalog No. Species Pres. Purity   Source  

Merlin
Merlin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Merlin
Merlin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for Merlin (3 products)

Catalog No. Species Pres. Purity   Source  

Neurofibromin 2 Lysate
Western Blot: Merlin Lysate [NBL1-13605] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for NF2
  Novus Biologicals Inc.

Neurofibromin 2 Lysate
Western Blot: Merlin Lysate [NBL1-13606] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for NF2
  Novus Biologicals Inc.

NF2 293T Cell Transient Overexpression Lysate(Denatured)
NF2 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

Recommended Secondary Antibodies for Merlin (9 products)

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Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat FITC Rb E, ICC/IF, WB
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Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat HRP Rb E, P, WB
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Rabbit IgG (H+L chain) antibody
Rabbit IgG (H+L chain) antibody Goat TRITC Rb E, F, ICC/IF
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Rabbit IgG F(ab)2 Fragment (H+L chain) antibody
Rabbit IgG F(ab)2 Fragment (H+L chain) antibody Donkey PE Rb F
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Rabbit IgG (H+L chain, adsorbed) antibody
Rabbit IgG (H+L chain, adsorbed) antibody Goat Cy2
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Rabbit IgG (H+L chain, adsorbed) antibody
Rabbit IgG (H+L chain, adsorbed) antibody Goat Cy3
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Rabbit IgG (H+L chain, adsorbed) antibody
Rabbit IgG (H+L chain, adsorbed) antibody Goat Cy5
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Click here to see all secondary antibodies for Merlin
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