AR03002PU-S Cystatin-B

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0.1 mg / €400.00
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Cystatin-B

Product Description for Cystatin-B

Cystatin-B.
Presentation: Purified

Properties for Cystatin-B

Product Category Proteins & Growth Factors
Quantity 0.1 mg
Synonyms CPI-B, CST6, CSTB, Liver thiol proteinase inhibitor, STFB, Stefin-B
Presentation Purified
Molecular weight 13 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P04080
Purity > 98 % by SDS PAGE
Add. information NCBI Accession No.: NP_000091
Background CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.
Concentration 1.0 mg/ml
General Readings
  1. Turk V, et al (1991) FEBS Lett. 285 (2): 213-9.
  2. Jarvinen M, et al, (1988) Acta Histochem. 82 (1): 5-18.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant Human CSTB, fused to His-tag, was expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF
Molecular weight:
13 kDa (118 aa), confirmed by MALDI-TOF
Format
Buffer System:
20mM Tris pH 8.0, 50mM NaCl
Endotoxin level:
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity:
>98% by SDS PAGE
State:
Liquid purified protein by using conventional chromatography
Purified
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