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AM00673PU-N Clostridium difficile Toxin A antibody

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1 mg / €720.00
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Quick Overview

Mouse anti Clostridium difficile Toxin A PCG4.1

AM00673PU-N

Product Description for Clostridium difficile Toxin A

Mouse anti Clostridium difficile Toxin A PCG4.1.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Clostridium difficile Toxin A

Product Category Primary Antibodies
Quantity 1 mg
Synonyms tcdA, toxA
Presentation Purified
Applications E
Clonality Monoclonal
Clone PCG4.1
Host Mouse
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P16154
Immunogen:
C. difficile Toxin A.
Hybridization of Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Isotype control AM03096PU-N
Add. information Centrifuge before opening to ensure complete recovery of vial contents.
Application ELISA (1/1000). 
Western Blot (Reported).
Background Clostridium difficile, or C. difficile, a gram positive anaerobic bacterium, is the major causative agent of colitis and diarrhoea that can occur following antibiotic intake. C. difficile infection is one of the most common hospital acquired infections. When C. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhoea and inflammation of the large intestine.
Concentration 1.16 mg/ml (OD280 nm, E1% = 14)
General Readings
  1. Aubry A, Hussack G, Chen W et al. Modulation of Toxin Production by the Flagellar Regulon in Clostridium difficile Infect Immun 2012 Oct. PubMed PMID: 22851750 (ELISA, WB, Bacteria).
  2. Goulding D, Thompson H, Emerson J, Fairweather NF, Dougan G, Douce GR. Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1. Infect Immun. 2009 Dec;77(12):5478-85. doi: 10.1128/IAI.00551-09. Epub 2009 Sep 14. PubMed PMID: 19752031. (Free PMC Article available, 8 images available)
  3. Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, et al. Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res. 2008 Dec 15;68(24):10205-14. doi: 10.1158/0008-5472.CAN-08-2149. PubMed PMID: 19074888. (Free PMC Article available, 5 images available)
  4. Kolling GL, Wu M, Alcantara-Warren C et al. Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production Gut Microbes 2012 Nov 1. PubMed PMID: 22895082 (WB, Bacteria).
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A Chromatography
Buffer System:
10mM Sodium Phosphate, pH 7.4 ± 0.2 containing 150 mM Sodium Chloride
Preservatives:
0.05% Sodium Azide
State:
Liquid purified (0.2µm filtered) IgG fraction (>90% pure by SDS-PAGE)
Purified
Specificity
Specificity:
This antibody reacts with C. difficile Toxin A.
Does not cross react with C. difficile Toxin B.

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