Product Description for Fibrinogen
Fibrinogen.
Presentation: Purified
Presentation: Purified
Properties for Fibrinogen
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 2 mg |
| Synonyms | FGA, FGB, FGG |
| Presentation | Purified |
| Source | Plasma |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Purity | Prepared by conventional and affinity techniques |
|---|---|
| Background | Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease. All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases. |
| Caution | Source material supplied to your facility has been tested for the detection of HIV antibody, Hepatitis B surface antigen, antibody to Hepatitis C, HIV 1 antigen(s), antibody to HTLV - I/II, and syphilis with FDA approved test kits. All units were found to be non-reactive/negative for these tests. Nevertheless, all products from human sources should be handled as potentially infectious. |
| Concentration | 5.3 mg/ml (OD280nm, E1% = 15.1) |
| Storage | Store the protein at -80°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Source | Human Plasma |
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