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BM5108 Desmoglein-3 antibody

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5 ml / €300.00
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Quick Overview

Mouse anti Human Desmoglein-3 Dsg-G194

BM5108

Product Description for Desmoglein-3

Mouse anti Human Desmoglein-3 Dsg-G194.
Presentation: Supernatant
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Desmoglein-3

Product Category Primary Antibodies
Quantity 5 ml
Synonyms 130 kDa pemphigus vulgaris antigen, CDHF6, Cadherin family member 6, DSG3, PVA
Presentation Supernatant
Reactivity Hu
Applications C, WB
Clonality Monoclonal
Clone Dsg-G194
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P32926
Immunogen:
Recombinant Human polypeptide Desmoglein 3 (C-terminal amino acids 920-940)
AA Sequence:
VSIPDPLQHGNYLVTETYSAS
GeneID:
1830
Application Immunoblotting (Western Blot).
Immunohistochemistry on Frozen Sections: Ready-to-use.
Incubation Time: 1 h at RT.
Recommendations: For better resolution, preincubation (directly after fixation) with 0.05-0.2% Triton X-100 for 5-10 min, depending on tissue type, is recommended (See Ref.2).
Background Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
General Readings
  1. Kurzen H, Moll I, Moll R, Schäfer S, Simics E, Amagai M, et al. Compositionally different desmosomes in the various compartments of the human hair follicle. Differentiation. 1998 Sep;63(5):295-304. PubMed PMID: 9810708.
  2. Schäfer S, Stumpp S, Franke WW. Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues. Differentiation. 1996 May;60(2):99-108. PubMed PMID: 8641550.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: One year from despatch.
Format
Preservatives:
0.09% Sodium Azide
State:
Liquid Culture Supernatant
Supernatant
Specificity
Specificity:
In Immunoblots of cytoskeletal preparations from Human epidermis the antibody reacts specifically with a 140 kD polypeptide typical for Desmoglein 3.
In Immunolocalization studies, the mab shows typical staining of basal and lower suprabasal layers of the epidermis and special regions of fetal and anagen hair follicles.
The staining pattern observed corresponds to those obtained with pemphigus vulgaris patient sera.
Cross-reaction with Desmogleins 1 and 2 was not detected.
Species:
Human.
Gene ID 1830

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