Product Description for MDC1
anti MDC1.
Properties: Control Peptide
Presentation: Purified
Properties: Control Peptide
Presentation: Purified
Properties for MDC1
| Product Category | Control Peptides |
|---|---|
| Target Category | |
| Quantity | 50 µg |
| Synonyms | KIAA0170, MDC1, Mediator of DNA damage checkpoint protein 1, NFBD1 |
| Presentation | Purified |
| Clonality | Polyclonal |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Polyclonal Antibodies (de) |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | Control peptide should be used at 1.0 µg per 1.0 µl of antiserum in per assay. |
| Background | MDC1 (Mediator of DNA damage checkpoint protein 1) plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, both within S phase and G2/M. It is thought to act as a scaffold protein during the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139. MDC1 is also involved in downstream events subsequent to the recruitment of these proteins. MDC1 has tandem repeat BRCT domains that are required for localisation to chromatin that flanks sites marked by S139 phosphorylated histone H2A.X. MDC1 is phosphorylated following exposure to ionising radiation (IR), ultraviolent radiation (UV), and hydroxyurea (HU). MDC1 is also phosphorylated during G2/M and during activation of the mitotic spindle checkpoint. |
| Concentration | 1.0 mg/ml (by weight) |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: 6 month from despatch. |
| Format |
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| Specificity |
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| Gene ID | 9656 |
Accessory Products
Recommended Secondary Antibodies for MDC1 (0 products)
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