Antibodies to DC-SIGN/CD209 - FocusOn 023

DC-SIGN, a 44 kDa type II transmembrane protein also known as CD209, is a dendritic cell receptor

Dendritic cells (DCs) that control immune responses were found to capture and transport HIV from the mucosal area to remote lymph nodes: It has been postulated that DC-SIGN (CD209) serves as a receptor for capture, trafficking, and transmission of HIV to T cells.

DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN; CD209 contains a C-type lectin binding domain and binds ICAM-3, ICAM-2, and HIV viruses.

Antibody Tools for the Detection of DC-SIGN

OriGene Technologies offers a full panel of antibodies to CD209 / DC-SIGN. These antibodies are available in several different formats and package sizes and are suitable for flow cytometry or Western blotting.

Fig.1: Cat.-No. AP19030PU-N CD209 antibody staining of Paraformaldehyde-Fixed HeLa by Immunofluorescence at 1/200 dilution.

Fig.2: Cat.-No. BM4011 CD209b/SIGN-R1 antibody staining of Mouse Spleen Frozen Section.

Available Antibody Panel to the dendritic cell receptor

CD209 antibody (DC-SIGN antibody / DCSIGN antibody)