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BA545X Protein C / PROC

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Protein C / PROC

BA545X

Product Description for Protein C / PROC

Protein C / PROC.
Presentation: Purified

Properties for Protein C / PROC

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Inactivator of coagulation factors Va and VIIIa, PROC1, Vitamin K-dependent protein C
Presentation Purified
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P04070
Purity Immunoaffinity chromatography.
Add. information Vial Contains Small Volume. Centrifuge Product Before Opening!
Background Protein C is a vitamin K dependent serine protease zymogen. Purified human activated protein C selectively destroys factors Va and VIII:C in human plasma and thus has an important anticoagulant role. Protein C deficiency has been associated with inherited thrombophilia. In its primary structure, protein C is similar to the prothrombin group of blood coagulation factors. It most closely resembles factor X.
Protein C is synthesized as a single chain; this precursor molecule is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain.
Caution All human source materials have tested negative for HIV1, HIV2, HCV antibodies, HBsAg, HIV-1 antigens, STS, anti-HB core, and anti-HTLV I & II. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.
Concentration 5.6 mg/ml (OD280 nm, E1% = 14.5)
General Readings
  1. Esmon, C.T., (1984), Progress in Thromb. and Hemosts., 10, 25.
  2. Stenflo, J., (1984), Semin. in Thromb. and Hemostas., 10, 109.
  3. Walker, F.J., et al., (1979), Biochim. Biophys. Acta, 571, 333.
  4. Haley, P.E., et al., (1989), J. Biol. Chem., 264, 16303.
  5. Jenny, R.J., et al., (1986), Prep. Biochem., 16, 227.
  6. Griffen, J.H., et al., (1982), Blood, 60, 261.
  7. Kisiel, W., et al., (1981), Methods Enzymol., 80, 320.
  8. Discipio, R.G., et al., (1979), Biochemistry, 18, 899.
  9. Bajaj, S.P., et al., (1981), Prep. Biochem., 11, 397.
Storage Store the antigen at -20°C
Avoid repeated freezing and thawing.
Shelf life: six months from despatch.
Source Human Plasma
Description
Description:
Human Protein C.< 0.02% APC activity is measured using a chromogenic substrate based assay. Isoelectric Point: 4.4-4.8
Molecular weight:
62 kDa
Format
Buffer System:
50% Glycerol/H2O (vol/vol), containing no preservatives. .
Purity:
Immunoaffinity chromatography.
State:
Liquid purified fraction.
Purified
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