AFAP1L2 antibody
Principal name
AFAP1L2 antibody
Alternative names for AFAP1L2 antibody
AFAP1-like protein 2, KIAA1914, XB130, Actin filament-associated protein 1-like 2
Ncbi ID
9606, NP_001001936.1, NP_001001936, NM_032550, NM_001001936, NP_115939, NP_001171267.1, NM_001177796, NM_146102
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB)
Background of AFAP1L2 antibody
AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3b, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA306798 | AFAP1L2 antibody |
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| Rabbit Polyclonal AFAP1L2 Antibody | |||||||
 |
Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, P, WB |
0.1 mg /
€415.00
|
|
| OriGene Technologies, Inc. | |||||||
 +2 additional images |
|||||||
| AP23877PU-N | AFAP1L2 (C-term) antibody |
||||||
 |
Rabbit | Purified | Hu, Ms, Rt | E, P, WB |
50 µg /
€425.00
|
||
| OriGene Technologies GmbH | |||||||
| +2 additional images |
|||||||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP303918 | AFAP1L2 (transcript variant 2) |
||||
| Recombinant protein of human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 2 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
| TP307705 | AFAP1L2 (transcript variant 1) |
||||
| Recombinant protein of human actin filament associated protein 1-like 2 (AFAP1L2), transcript variant 1 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€748.00
|
|
| OriGene Technologies, Inc. | |||||
Lysates
| Catalog No. | ||
|---|---|---|
| LY424282 | AFAP1L2 overexpression lysate |
|
 |
0.1 mg /
€295.00
|
|
| OriGene Technologies, Inc. |
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR210554L2V | Lenti ORF particles, Afap1l2 (GFP-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,470.00
|
|
| OriGene Technologies, Inc. | ||
| MR220202L2V | Lenti ORF particles, Afap1l2 (GFP-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 3, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,560.00
|
|
| OriGene Technologies, Inc. | ||
| MR210554L1V | Lenti ORF particles, Afap1l2 (Myc-DDK-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,330.00
|
|
| OriGene Technologies, Inc. | ||
| MR220202L1V | Lenti ORF particles, Afap1l2 (Myc-DDK-tagged) - Mouse actin filament associated protein 1-like 2 (Afap1l2), transcript variant 3, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,400.00
|
|
| OriGene Technologies, Inc. | ||
