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ANKRD11 antibody

Principal name

ANKRD11 antibody

Alternative names for ANKRD11 antibody

ANCO1, Ankyrin repeat-containing cofactor 1, Ankyrin repeat domain-containing protein 11

SwissProt ID

Q6UB99

Gene ID

29123 (ANKRD11)

Ncbi ID

NP_037407.4

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of ANKRD11 antibody

Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functiol domains: a conserved N-termil ankyrin repeat domain (ARD(consisting of 22-24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-termil regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell sigling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.

Immunohistochemistry: ANKRD11 Antibody - Most of the normal cells showed strong nuclear positivity with an additional weaker cytoplasmic staining in many cases. Liver was weakly stained. Malignant cells displayed moderate to strong immunoreactivity. Image and statement courtesy of the Human Protein Atlas (HPA).

TA590542

Immunohistochemical staining of human rectum shows strong nuclear and a weaker cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

TA590542

Immunofluorescent staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli & cytoplasm.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

TA590542

Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 11; Lane 2: RT-4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: TonsilThis validation was performed by Protein Atlas and the presentation of data is for informational purposes only.

TA590542

TA590542

ELISA: ANKRD11 Antibody

TA590542

WB Suggested Anti-ANKRD11 Antibody Titration: 1.25 ug/ml; Positive Control: Human Placenta

TA333877

Human kidney

TA333877

Primary Antibodies

Catalog No.	Host	Iso.	Pres.	React.	Applications
TA590542	ANKRD11 antibody
	Rabbit Polyclonal ANKRD11 Antibody
	Rabbit	IgG	Purified	Hu	E, ICC/IF, P, WB	0.1 mg / €409.00
						OriGene Technologies, Inc.
+5 additional images	Highly validated antibody!

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