basic Cytokeratin antibody
Principal name
basic Cytokeratin antibody
Available reactivities
Available hosts
Available applications
Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoelectron Microscopy (EM)
Background of basic Cytokeratin antibody
Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1 (67), CK2 (65.5), CK3 (64), CK4 (59), CK5 (58), CK6 (56), CK7 (54), CK8 (52.5) and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10 (56.5), CK12 (56), CK13 (53), CK14 (50), CK16( 48), CK17 (46), CK18 (45), CK19(48) and CK20(46).
General readings
Mikaelian, I. et al. (2004). Antibodies That Label Paraffin-Embedded Mouse Tissues: A Collaborative Endeavor. Toxicology Pathology 32:181-191.
Clausen, H. et al. (1986). Differentiation-dependent expression of keratins in human oral epithelia. J. Invest. Dermatol. 86:249-254.
Sun, T-T, et al. (1985). Monoclonal antibody studies of mammalian epithelial keratins: a review. Ann. N.Y. Acad. Sci. 455:307-329.
Spagnolo, D.V. et al. (1985). Monoclonal anti-keratin (AE1) reactivity in routinely processed tissue from 166 human neoplasms. Am. J. Clin. Path. 84:697-704.
